Using five strands of hair, scientists have deciphered the genome of one of the greatest composers in history, Ludwig van Beethoven, nearly two centuries after his death. This has allowed them to gain a better understanding of the liver disease that led to his death, rather than his hearing loss. Researchers announced today that his genome revealed he had a genetic predisposition to liver diseases and was also infected with hepatitis B.
An autopsy conducted after his death in 1827 at the age of 56 in Vienna showed he suffered from cirrhosis, a condition often resulting from excessive alcohol consumption. The new findings indicate multiple factors contributed to his illness, including genetic factors, viral infections, and alcohol consumption. The presence of hepatitis B virus integrated into Beethoven's genome suggests he was infected with a liver infection at least a few months prior to his death, possibly even earlier.
Beethoven experienced a gradual loss of hearing starting at age 29, eventually leading to total deafness by age 44. However, he continued to compose his magnificent works. Scientists, however, have been unable to find a genetic explanation for Beethoven's hearing loss.
