The "NASDAQ" and "S&P 500" indexes closed down on Wednesday, as investors rushed to take profits after a months-long rally in major company stocks, and ahead of inflation data and the Federal Reserve's interest rate meeting next week. The "Dow Jones Industrial Average" rose by 0.27% to 33,665.02 points, while the "S&P 500" dropped by 0.38% to 4,267.52 points, and the "NASDAQ Composite" fell by 1.29% to 13,104.90 points.