Major indices on Wall Street opened lower on Friday, as investor sentiment continued to be affected by remarks from Federal Reserve Chairman Jerome Powell, suggesting the possibility of further interest rate hikes during his two-day semiannual testimony before Congress. The Dow Jones Industrial Average dropped by 111.05 points or 0.33% to 33,835.66 points. The S&P 500 index fell by 27.72 points or 0.63% to 4,354.17 points. The Nasdaq composite index fell by 146.51 points or 1.07% to 13,484.10 points.