European stocks closed lower on Wednesday, led by losses in mining and travel companies, as optimism about imminent interest rate cuts continued to wane. Investors are also watching a crucial inflation reading from the U.S. set to be released later this week. The Stoxx 600 index closed down 0.2%, with the travel and leisure sector leading sector losses, falling 1.1%. The basic resources index also decreased by 1.1%, marking the third consecutive day of losses. Energy stocks dropped by 0.9%, marking their fourth straight session of declines amid falling oil prices. However, the healthcare index continued its recent strong performance, gaining 0.3%, which helped mitigate the losses.