The Korean Institute of Biological Science and Biotechnology has developed a 3D bioprinting technology using natural killer (NK) cells as a new method for cancer immunotherapy. According to a study published in the journal Biomaterials Research, allowing the 3D-printed hydrogels to encapsulate NK cells helps prevent the loss of these cells, enabling most of them to return to cancer cells.
The pores in the hydrogel allow for the release of NK cells, which retain their viability after a certain period, thus facilitating immune functions. Although NK cells are generally used in immunotherapy, the method of injecting NK cells intravenously has not shown effective results in clinical trials for solid tumors, as NK cells cannot maintain appropriate viability and fail to target solid tumors.
With the newly developed technology, NK cells can be injected into the hydrogel, printed, and then implanted in a 3D environment, enhancing the viability and activity of NK cells and enabling them to confront cancerous tissues. The lead researcher, Su Ai Park, stated, "This technology can significantly improve the functions of NK cells used in cancer treatment. We expect to contribute to cancer patients' treatments through this newly developed technology."
